Dr. Prajapati grew up in New Delhi, and received his bachelor’s degree from University of Delhi, India. In master’s, he studied Biochemistry in Jamia Hamdard University, New Delhi. He received his Ph.D. in Biochemistry in 2014 under the supervision of Professor (Dr.) Shyam S. Chauhan from All India Institute of Medical Sciences (AIIMS), New Delhi. During his Ph.D. course, Dr. Prajapati studied the expression and function of dipeptidyl peptidase III, a Zn2+ dependent aminopeptidase, in multiple human tumor derived cell lines and cancer tissues using high throughput molecular biology and proteomics approaches. He joined Dr. Kleinman’s lab in February 2014 and studying oxidative stress and epigenetic regulation in aging and age-related macular degeneration (AMD). Outside the lab, he spends time with his wife Lalti and talks to his family.
Hometown: Lexington, KY
Education: B.A., Biology, Berea College
Interests: Science, football, cooking, and making sure that everything is organized and functional!
Hometown: Louisville, KY
Education: B.S. in Biology from the University of Kentucky
Interests: Cooking, listening and making music, power lifting, and fishing
Hometown: Nanchang, China
Education: Institute of Metallurgy, Academia Sinica (Shanghai, China) Master of Science in Analytical Chemistry; University of Jiangxi (Nanchang, China), Bachelor of Science in Analytical Chemistry
We are investigating Histone deacetylases (HDAC) which are part of an epigenetic regulatory system serving as a unique control of the chromatin remodeling process, determining the transcriptional availability of any given gene. HDAC inhibitors (HDACi) are reported to suppress neovascularization in various mouse models and have become a novel target for the epigenetic regulation of critical pathways in neurodegenerative diseases including AMD. Heterogeneous effects of HDAC function occur depending on the target locus and the tissue type as HDACi can trigger both pro- and anti-inflammatory effects in a range of inflammation-relevant cell types. These effects include changes in pro- inflammatory eotaxin expression. We aim to establish the effects of broad band chemical HDACi on eotaxin expression and the correlation to cell death.
Kyung Jung, MS: Laboratory Technician
Hometown: Ulsan, South Korea
Education: B.S. of Genetic Engineering at Chosun University, South Korea, M.S. of Toxicology at University of Kentucky
Interests: Soccer, travel
Kabhilan received his PhD from Iowa State University under the mentorship of Sinisa Grozdanic and trained with Randy Kardon during this period.
His main interest is in the development of novel diagnostics that enable early detection of aging diseases, specifically of the retina. He dreams of a day when a routine eye check, conducted from the comfort of one’s home using a smartphone, would provide detailed molecular health of the retina.
Continue reading Kabhilan Mohan, PhD
I am a physician-scientist at East Tennessee State University specializing in diseases of the retina and vitreous. My research efforts are committed to conducting basic science investigations on neovascular and degenerative eye diseases with specific emphases on aging, inflammation and molecular imaging of early pathological changes to the retina and choroid.
We’re happy to welcome you to the Kleinman Laboratory of Ocular Biology and Imaging!