Category Archives: Researchers

Sushil Dubey, PhD

I hail from Lucknow, a city famed as the cultural center of northern India. After completing my bachelor’s degree in chemistry and botany from Lucknow University, I migrated to south India with a fellowship from the Department of Biotechnology (Ministry of Science and Technology, Government of India) to pursue my masters in Biotechnology at Madurai Kamaraj University, India. I qualified the national level GATE exam and started my doctoral program under the mentorship of Dr. P. Sundaresan at the Department of Genetics, Aravind Medical Research Foundation. The focus of my doctoral study was identification and characterization of genes associated with congenital globe anomalies.
With a specific interest to work in the field of genetics and epigenetics of ocular diseases, I applied to Dr. Kleinman’s lab for a postdoctoral position and joined the group in July 2015. During my tenure as a postdoc at UK, I will be exploring the epigenetic regulation and transcriptional repression mediated through histone deacetylase complexes in aging retina and AMD. Data from our lab showed altered expression of HDAC1 and 2 in advanced dry AMD. HDACs (HDAC1 and 2) function in different multiprotein corepressor complexes (mainly Sin3, NuRD and CoREST) that are associated with sequence-specific DNA-binding proteins, which are thought to target the complexes to specific genes, leading to local chromatin modification. The main focus of my research will be to identify the role of these corepressor complexes and subsequent transcriptomic effects in aging retina and AMD.
Outside my research, I like to spend time with my wife and daughter. I also like to travel and look forward to explore and experience all the good things that the Bluegrass State has to offer.

Subhash C. Prajapati, PhD

Subhash Prajapati, PhD
Subhash Prajapati, PhD
Dr. Prajapati grew up in New Delhi, and received his bachelor’s degree from University of Delhi, India. In master’s, he studied Biochemistry in Jamia Hamdard University, New Delhi. He received his Ph.D. in Biochemistry in 2014 under the supervision of Professor (Dr.) Shyam S. Chauhan from All India Institute of Medical Sciences (AIIMS), New Delhi. During his Ph.D. course, Dr. Prajapati studied the expression and function of dipeptidyl peptidase III, a Zn2+ dependent aminopeptidase, in multiple human tumor derived cell lines and cancer tissues using high throughput molecular biology and proteomics approaches. He joined Dr. Kleinman’s lab in February 2014 and studying oxidative stress and epigenetic regulation in aging and age-related macular degeneration (AMD). Outside the lab, he spends time with his wife Lalti and talks to his family.

Kyung Jung, MS

Kyung Jung, MS
Kyung Jung, MS
Kyung Jung, MS: Laboratory Technician

Hometown: Ulsan, South Korea

Education: B.S. of Genetic Engineering at Chosun University, South Korea, M.S. of Toxicology at University of Kentucky

Interests: Soccer, travel

Kabhilan Mohan, PhD

Kabhilan Mohan, PhD, Post-doctoral researcher
Kabhilan Mohan, PhD, Post-doctoral researcher
Kabhilan received his PhD from Iowa State University under the mentorship of Sinisa Grozdanic and trained with Randy Kardon during this period.

His main interest is in the development of novel diagnostics that enable early detection of aging diseases, specifically of the retina. He dreams of a day when a routine eye check, conducted from the comfort of one’s home using a smartphone, would provide detailed molecular health of the retina.
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Mark Kleinman, MD

Mark Kleinman, MD, MS, Principal Investigator in the Ocular Biology and Imaging Lab at the University of Kentucky
Mark Kleinman, MD, Principal Investigator in the Ocular Biology and Imaging Lab at the East Tennessee State University Quillen College of Medicine

I am a physician-scientist at East Tennessee State University specializing in diseases of the retina and vitreous. My research efforts are committed to conducting basic science investigations on neovascular and degenerative eye diseases with specific emphases on aging, inflammation and molecular imaging of early pathological changes to the retina and choroid.

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