OCULAR BIOLOGY & IMAGING LAB at EAST TENNESSEE STATE UNIVERSITY

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  • The Kleinman Laboratory for Ocular Biology and Imaging
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Molecular Imaging in the Human Eye

October 13, 2014 S. Lee Ware

We are working hard to develop new diagnostic imaging technologies to combat AMD.

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Previous PostJennifer BrownNext PostSubhash C. Prajapati, PhD

Lab Contact

East Tennessee State University
James H. Quillen College of Medicine
Bldg 119 Rm 1-04
Johnson City, TN 37614
Department of Surgery
Ph (423) 439-5969
Fax (423) 439-6251
Email: kleinman@etsu.edu

Regarding Open Positions & Inquiries

We are always looking for highly self-motivated and creative individuals with an M.D. or doctoral-level training in the biological sciences. Our laboratory has several exciting and advanced avenues of investigation in non-invasive molecular-scale imaging modalities for aging retinal diseases and a program focused on dissecting the role of epigenetic regulation of inflammation and cell death in photoreceptors and retinal pigment epithelium.

Depending on project assignment, the candidate will gain critical skills in novel techniques in multi-modal small animal imaging, custom fluorophore bio-conjugate engineering, mass spectrometry based proteomics, massively parallel sequencing, bioinformatics pipelines, analyses to assess histone binding and modifications in genomic DNA, and numerous other advanced molecular biology techniques. Significant experience will be offered in the design and interpretation of experiments as well as grantsmanship to prepare the candidate for a successful independent career as a principal investigator in the biomedical sciences.

Candidates must be willing and comfortable working with rodents. Two year of eligibility and commitment as postdoctoral scholar is required. Preference will be given to those with experience in ocular biology specifically in the posterior segment, vascular biology, vision, neuroscience or aging research. Salary will be based on University guidelines for postdoctoral fellows, and will be commensurate with experience.

Interested applicants please submit CV, brief statement of interest and career goals, contact information and three references. In the CV, please list your technical expertise, especially in animal dissection and surgeries, optical coherence tomography, electrophysiology, histology/imaging/microscopy, mass spectrometry, massively parallel sequencing, bio-informatics, or other advanced techniques in molecular biology.

  • The Kleinman Laboratory for Ocular Biology and Imaging
  • About Our Research
  • Team
    • Mark Kleinman
    • Researchers
    • Staff
    • Alumni
  • Publications

Most Recent Lab News

  • Sushil Dubey, PhD
  • Subhash C. Prajapati, PhD
  • Molecular Imaging in the Human Eye
  • Jennifer Brown
  • Jacob Roney

Online Resources

  • Ambati Lab Lab of J. Ambati
  • Webvision – University of Utah Online Retina Texbook

RSS PubMed Record

  • Long-Term Evaluation of Retinal Morphology and Function in Rosa26-Cas9 Knock-In Mice
  • Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration
  • Imaging data on characterization of retinal autofluorescent lesions in a mouse model of juvenile neuronal ceroid lipofuscinosis (CLN3 disease)
  • Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium
  • Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease)
  • Complement Activation and Inhibition in Retinal Diseases
  • Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration
  • Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome
  • The Immune System and AMD
  • Clocking in on diabetic retinopathy

RSS Medscape Eye

  • Low-Dose Atropine Improves Myopia in Children
  • Cornea Donation Rules May Ease for Gay, Bisexual Men
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