OCULAR BIOLOGY & IMAGING LAB at EAST TENNESSEE STATE UNIVERSITY

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  • The Kleinman Laboratory for Ocular Biology and Imaging
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    • Mark Kleinman
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Molecular Imaging in the Human Eye

October 13, 2014 S. Lee Ware

We are working hard to develop new diagnostic imaging technologies to combat AMD.

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Previous PostJennifer BrownNext PostSubhash C. Prajapati, PhD

Lab Contact

East Tennessee State University
James H. Quillen College of Medicine
Bldg 119 Rm 1-04
Johnson City, TN 37614
Department of Surgery
Ph (423) 439-5969
Fax (423) 439-6251
Email: kleinman@etsu.edu

Regarding Open Positions & Inquiries

We are always looking for highly self-motivated and creative individuals with an M.D. or doctoral-level training in the biological sciences. Our laboratory has several exciting and advanced avenues of investigation in non-invasive molecular-scale imaging modalities for aging retinal diseases and a program focused on dissecting the role of epigenetic regulation of inflammation and cell death in photoreceptors and retinal pigment epithelium.

Depending on project assignment, the candidate will gain critical skills in novel techniques in multi-modal small animal imaging, custom fluorophore bio-conjugate engineering, mass spectrometry based proteomics, massively parallel sequencing, bioinformatics pipelines, analyses to assess histone binding and modifications in genomic DNA, and numerous other advanced molecular biology techniques. Significant experience will be offered in the design and interpretation of experiments as well as grantsmanship to prepare the candidate for a successful independent career as a principal investigator in the biomedical sciences.

Candidates must be willing and comfortable working with rodents. Two year of eligibility and commitment as postdoctoral scholar is required. Preference will be given to those with experience in ocular biology specifically in the posterior segment, vascular biology, vision, neuroscience or aging research. Salary will be based on University guidelines for postdoctoral fellows, and will be commensurate with experience.

Interested applicants please submit CV, brief statement of interest and career goals, contact information and three references. In the CV, please list your technical expertise, especially in animal dissection and surgeries, optical coherence tomography, electrophysiology, histology/imaging/microscopy, mass spectrometry, massively parallel sequencing, bio-informatics, or other advanced techniques in molecular biology.

  • The Kleinman Laboratory for Ocular Biology and Imaging
  • About Our Research
  • Team
    • Mark Kleinman
    • Researchers
    • Staff
    • Alumni
  • Publications

Most Recent Lab News

  • Sushil Dubey, PhD
  • Subhash C. Prajapati, PhD
  • Molecular Imaging in the Human Eye
  • Jennifer Brown
  • Jacob Roney

Online Resources

  • Ambati Lab Lab of J. Ambati
  • Webvision – University of Utah Online Retina Texbook

RSS PubMed Record

  • Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration March 21, 2021 Patricia A D'Amore
  • Imaging data on characterization of retinal autofluorescent lesions in a mouse model of juvenile neuronal ceroid lipofuscinosis (CLN3 disease) September 5, 2020 Mark E Kleinman
  • Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium June 28, 2020 Qing Jun Wang
  • Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease) January 11, 2016 Qing Jun Wang

RSS Medscape Eye

  • Gene Therapy Shows Potential for RPE65-Related Retinal Dystrophy October 6, 2022
    The rare genetic retinal disorder results in severe visual impairment. Medscape Medical News
  • Normal-Tension Glaucoma Linked to Alzheimer’s Risk October 6, 2022
    The findings put ophthalmologists, primary care physicians, and neurologists on notice to use normal-tension glaucoma as a biomarker for AD screening. Medscape Medical News
  • Study Links Poor Physical Fitness to Children's Eye Allergies October 5, 2022
    Children who were less physically fit and lived in urban settings are more vulnerable to ocular allergies. Medscape Medical News
  • Combined Glaucoma + Cataract Surgery as Effective as Separate October 4, 2022
    A national registry study of 153,000 eyes found that glaucoma surgery done during cataract procedures had lower failure rates than doing two separate operations. Medscape Medical News
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