OCULAR BIOLOGY & IMAGING LAB at EAST TENNESSEE STATE UNIVERSITY

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The Kleinman Laboratory for Ocular Biology and Imaging
About Our Research
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Welcome to the Kleinman Laboratory of Ocular Biology and Imaging

October 10, 2014 S. Lee Ware

We’re happy to welcome you to the Kleinman Laboratory of Ocular Biology and Imaging!

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Next PostMark Kleinman, MD

Lab Contact

East Tennessee State University
James H. Quillen College of Medicine
Bldg 119 Rm 1-04
Johnson City, TN 37614

Department of Surgery

Ph (423) 439-5969
Fax (423) 439-6251
Email: kleinman@etsu.edu

Regarding Open Positions & Inquiries

We are always looking for highly self-motivated and creative individuals with an M.D. or doctoral-level training in the biological sciences. Our laboratory has several exciting and advanced avenues of investigation in non-invasive molecular-scale imaging modalities for aging retinal diseases and a program focused on dissecting the role of epigenetic regulation of inflammation and cell death in photoreceptors and retinal pigment epithelium.

Depending on project assignment, the candidate will gain critical skills in novel techniques in multi-modal small animal imaging, custom fluorophore bio-conjugate engineering, mass spectrometry based proteomics, massively parallel sequencing, bioinformatics pipelines, analyses to assess histone binding and modifications in genomic DNA, and numerous other advanced molecular biology techniques. Significant experience will be offered in the design and interpretation of experiments as well as grantsmanship to prepare the candidate for a successful independent career as a principal investigator in the biomedical sciences.

Candidates must be willing and comfortable working with rodents. Two year of eligibility and commitment as postdoctoral scholar is required. Preference will be given to those with experience in ocular biology specifically in the posterior segment, vascular biology, vision, neuroscience or aging research. Salary will be based on University guidelines for postdoctoral fellows, and will be commensurate with experience.

Interested applicants please submit CV, brief statement of interest and career goals, contact information and three references. In the CV, please list your technical expertise, especially in animal dissection and surgeries, optical coherence tomography, electrophysiology, histology/imaging/microscopy, mass spectrometry, massively parallel sequencing, bio-informatics, or other advanced techniques in molecular biology.

The Kleinman Laboratory for Ocular Biology and Imaging
About Our Research
Team
Publications

Most Recent Lab News

Sushil Dubey, PhD
Subhash C. Prajapati, PhD
Molecular Imaging in the Human Eye
Jennifer Brown
Jacob Roney

PubMed Record

Histone deficiency and hypoacetylation in the aging retinal pigment epithelium
Unraveling Histone Loss in Aging and Senescence
Long-Term Evaluation of Retinal Morphology and Function in Rosa26-Cas9 Knock-In Mice
Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration
Imaging data on characterization of retinal autofluorescent lesions in a mouse model of juvenile neuronal ceroid lipofuscinosis (CLN3 disease)
Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium
Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease)
Complement Activation and Inhibition in Retinal Diseases
Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration
Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome

Medscape Eye

Open-Angle Glaucoma Dx: Polygenic Risk Score Found Useful
Revamped Antibiotic May Treat Deadly Eye Infection
FDA OKs High Concentration of Adalimumab Biosimilar Cyltezo

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